English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

One of the great obstacles in developing therapeutic agents based on biomacromolecules, including peptides, proteins, and nucleic acids, should be their low membrane permeability due to their high hydrophilicity and large molecular sizes. On the other hand, there is a growing research interest in intracellular delivery of biomacromolecules using arginine-rich cell-penetrating peptides (CPPs). Chemical conjugation of bioactive macromolecules with these CPPs allows efficient translocation of these molecules into cells. Successful intracellular delivery of various nano-particles using CPPs have also been reported. Involvement of macropinocytosis has been reported as an internalization mechanism of arginine-rich CPPs. Accumulation of arginine-rich CPPs and their conjugates on cell surfaces by the interaction of membrane associated proteoglycans and the eventual induction of macropinocytosis can be a rationale to explain the high efficacy of the intracellular delivery.

Internalization of Arginine-rich Cell-penetrating Peptides and Delivery of Biomacromolecules into Cells