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It is important to control intracellular trafficking of genes as well as drugs for developing a new drug delivery system. Plasma membrane and endosomal membrane are considered to be strong barriers for hydrophilic, high molecular weight compounds such as DNA. Virus are sophisticated gene delivery carriers which can overcome these barriers using specific peptides to bind cell surface receptors or to fuse with plasma or endosomal membranes. In this review, we will focus on the interaction between these biomembranes and virus peptides as well as recently synthesized fusogenic peptides to utilize them for developing a new delivery system.

Controlled Intracellular Trafficking Using Plasma and Endosomal Membrane Interactive Peptides.