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As a typical example for the product separation in bioreactors to produce neutral amino acids from the corresponding organic acids, separation of the mixture of lactate and L-alanine was attempted by the method with negatively charged sulfonated polysulfone reverse osmosis membrane and by the electrodialysis with ion exchange membranes. By one step electrodialysis, lactate and L-alanine could be completely separated from each other. The same method will be commonly applicable to the most of bioreactor processes for neutral amino acids being investigated extensively.

Product separation in bioreactors to produce neutral amino acids from the corresponding organic acids.