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The discovery of antibiotic to combat bacterial infections, has been a lifesaving discovery. But, gradually due to more dependency and continuous use of antibiotics, instead of becoming a boon, it gradually tends more towards the negative aspect of development of antibiotic resistance. Eventually, the bacteria started developing resistance to the antibiotics. This has opened the door for researchers to learn more about how antibiotic resistance genes (ARG) evolve and lead to antibiotic resistance in bacteria. The present review focused on the use of two major antibiotics which are widely used now a days (Streptomycin and Oxytetracycline) emphasizing more on the mechanism of development of resistance in the bacteria and their impact on antibiotic resistance. Researchers are also trying continuously to develop some alternative antimicrobial drugs which will have minimum risk of antibiotic resistance. Antibiotic resistance is a risk that must be considered; else, a bleak future awaits

Life Without Antibiotics? - A Review on Increasing Threat of Antibiotic Resistance with A Broader Look on Agricultural aspect