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The acidic saline animal model of pain has been suggested to mimic fibromyalgia (PM). Oligomeric proanthocyanidin complexes (OPC) from grape seeds are known to act as an antioxidant. We studied the effects of OPC on the pain threshold in the acidic saline animal model of pain. The left gastrocnemius muscle was injected with 100 μl of saline at pH 4.0 under brief isoflurane anesthesia on days o and 5. Control rats (n=5) received identical injections of physiological saline (pH 7.2) on the same schedule. Rats (n=10) with acidic saline injection were separated into two study subgroups. After measurement of pre-drug pain thresholds, rats were injected intraperitoneally with either saline or OPC 300 ㎎/㎏. Paw withdrawal thresholds to pressure were again measured 60 min after intra-peritoneal injection. Nociceptive thresholds were measured with a Dynamic Plantar Aesthesiometer by applying an increasing pressure to right or left hind paw until the rat withdrew the paw. Compared to baseline (day 0), acid injections produced mechanical hyper-responsiveness on day 7 (pre-drug) in these rats [p0.05]. A potent antihyperalgesic effect was observed when rats were injected intra-peritoneally with OPC 300 ㎎/㎏ [injected paw, p=0.001; contralateral paw, p=0.002]. OPC treatment decreased the expression of acid sensing ion channel 3 in the brain motor cortex area on immunohistochemical staining when OPC 300 ㎎/㎏ was administered intraperitoneally in the animal model of FM pain [p0.05]. Further research is required to determine the efficacy of OPC treatments in FM pain in humans.

Analgesic Effect of Grape Seed Proanthocyanidin Extract in Fibromyalgia Animal Model