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Vacuum-assisted closure (VAC) has been used to manage nearly every type of wound seen in orthopedic field including early prosthetic hip and knee infections. In this study, we aimed to present our treatment results of two patients with total and proximal femoral mega prosthesis respectively. Case Series: With the diagnosis of periprosthetic infection, in both cases, prosthesis were disassembled and sterilized in autoclave. Prosthesis were reimplanted after sterilization and Vacuum Assisted Closure system with instillation. Patients were successfully treated and no signs of infection were detected until ten to twelve months postoperatively. Conclusion: Mega prosthetic infections pose a great challenge Yalçın Turhan1, Korhan Özkan2, Esat Uygur3, Murat Demiroğlu4, Bülent Erol5, Hüseyin Çoban6 Affiliations: 1Assistant Professor, Orthopedics and Traumatology Department, Duzce University Medical Faculty, Duzce, Turkey; 2Professor, Orthopedics and Traumatology Department, Medeniyet University Medical Faculty, Istanbul, Turkey; 3Assistant Professor, Orthopedics and Traumatology Department, Medeniyet University Medical Faculty, Istanbul, Turkey; 4MD, Orthopedics and Traumatology Department, Medeniyet University Medical Faculty, Istanbul, Turkey; 5Professor, Orthopedics and Traumatology Department, Marmara University Medical Faculty, Istanbul, Turkey; 6MD, Infectious Diseases and Clinical Microbiology, ELAB, Istanbul, Turkey. Corresponding Author: Yalçın Turhan, Medical Faculty of Duzce University, Department of Orthopaedics and Traumatology, Konuralp Street, Center, Duzce, Turkey; Email: yturhan_2000@yahoo.com Received: 03 July 2018 Accepted: 31 July 2018 Published: 22 August 2018 S RIES PEER REVIEWED | OPEN A CE S to an orthopedic surgeon and the patient. Besides its economic cost, it causes significant morbidity to the patient. Intermittent negative pressure wound therapy with instillation may be promising technique for the treatment of devastating infections associated with tumor prosthesis.

Treatment of early chronic infections with tumor prosthesis by intermittent negative pressure wound therapy with instillation