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The present investigation was aimed to identify the potentiality of  Euphorbia thymifolia  Linn. and  Euphorbia hirta  Linn. leaf extract on the toxin-induced (carbon tetrachloride - CCl 4 ) Albino Wistar rats. The animals were grouped into 7 categories including control (basal diet, G1), CCl 4 -induced (1.5 mL/kg, b.w., i.p.) (G2), G1 administrated with 300 mg/kg b.w., extract of  E. thymifolia  (G3) and  E. hirta  (G4), G2 administrated with 300 mg/kg b.w., extract of  E. thymifolia  (G5),  E. hirta  (G6), and standard drug (silymarin 25 mg/kg b.w.; G7) for 21-days trial period with each group contains 6 rats. The samples were collected and the following parameters including mitochondrial enzymes, different ATPase and lipid profiles were analyzed. The membrane-bound enzymes, the mitochondrial enzymes levels and the lipid profiles were reduced in the toxin-induced rats but the levels of enzymes were restored, significantly increased and lipid profiles are returned to the normal in the treatment of both extracts.

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Effects of &lt;i&gt;Euphorbia thymifolia&lt;/i&gt; and &lt;i&gt;Euphorbia hirta&lt;/i&gt; leaf extracts on membrane-bound, mitochondrial enzymes and lipid profile of carbon tetrachloride-induced hepatotoxicity in rats