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ABS TRACT Objective: In this study, it was aimed to investigate the effects of oleuropein on NO and oxidantantioxidant levels of tissues in metformin and insulin treated streptozotocin-diabetic rats. Material and Methods: 40 male Sprague-Dawley rats were used in this study. Animals were divided into 5 groups (n=8) in which 3 experiment and 2 control. Isotonic NaCl solution was injected intraperitoneally (ip) to the Control. 50 mg/kg STZ was given ip to the Diabetic Control, 50 mg/kg streptozotocin (STZ)+100 mg/kg Metformin+4 IU/kg insulin was given ip to the Group 1, 50 mg/kg STZ+100 mg/kg Metformin+4 IU/kg insulin was given ip and 30 mg/kg oleuropein was given orally to the Group 2 and 50 mg/kg STZ ip and 30 mg/kg oleuropein was given orally to the Group 3. Results: Metformin and insulin with oleuropein have a synergistic effect on regulatory activity of the GSH, MDA, NO levels and GSHPx activities of the kidney, brain and heart tissues. Using of metformin and insulin with oleuropein was increased the GSH levels of the kidney (P<0.001), brain (P<0.001) and heart tissues (P<0.05); also increased the GSHPx activity of the brain (P<0.01) and the heart tissues (P<0.001) and reduced MDA and NO levels of the kidney, brain and heart tissues (P<0.001). There were no statistically differences in GSHPx activity of kidney tissues of experimental groups. Conclusion: Using of oleuropein, on streptozotocin-diabetics, in combination with metformin and insulin seems to synergistic effect on the antioxidants on kidney, brain and heart tissues and effective in regulating the NO level on tissues.

türkiye klinikleri veteriner bilimleri dergisi/türkiye klinikleri veteriner bilimleri

Effects of Oleuropein on Nitric Oxide, Glutathione, Malondialdehyde Levels and Glutathione Peroxidase Activities in Various Tissues of Streptozotocin-Induced Diabetic Rats Treated with Metformin and Insulin