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ABS TRACT Objective: To investigate the effect of ND:YAG laser capsulotomy on macular pigment optical density(MPOD) in patients with posterior capsule opacification(PCO). Material and Methods: This prospective and single-arm clinical trial included 38 participants with pseudophakic eyes. MPOD, choroidal(CT) and central macular thicknesses(CMT), as well as anterior chamber parameters, were measured before ND:YAG laser and the measurements were repeated after one week, one month and two months. The changes in the parameters and correlations were evaluated statistically. Results: There were significant decreases in the MPODs of the fovea and pericentral during the study (p<0.01 for both). The mean ICA (iridocorneal angle), ACD (anterior chamber depth) and CMT significantly increased during the study period (p<0.01). The mean CTs of the nasal and subfoveal regions also increased significantly (p<0.01). There were significant negative correlations between the changes in the mean total applied laser energy and MPODs (r>0.6, p<0.01), and there were significant and same direction relations between the changes in the mean total laser energy, and ICA, ACD, as well as CMT(r>0.6, p<0.01). Conclusion: Posterior laser capsulotomy resulted in decreases in MPODs, while there were increases in the mean ICA, ACD, CT and CMT. Laser capsulotomy can affect the posterior capsule integrity and macular pigment, therefore, it can cause more vulnerable situations in the retina against high-energy blue lights.

The Effect of Nd:YAG Laser Posterior Capsulotomy on Macular Pigment Optical Density in Cases with Posterior Capsule Opacification