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Objective: The aim of this study was to investigate the correlation between short-wave fundus autofluorescence (FAF) and spectral-domain optical coherence tomography (SD-OCT) measures in patients with diabetic cystoid macular edema. Material and Methods: FAF and SD-OCT measurements were recorded from 123 eyes of 84 patients. The patients were grouped and compared according to their FAF grades as follows: grade 1 (group 1, n=27), grade 2 (group 2, n=27), grade 3 (group 3, n=32), and grade 4 (group 4, n=37). FAF graded manually by single grader. The groups were compared in terms of OCT findings (central macular thickness (CMT), total macular volume (TMV), and IS/OS band integrity) with FAF type (single lobule, multi-lobular or mixed) and FAF grade. Results: Group 1 and 2 patients primarily had single lobule FAF patterns, and groups 3 and 4 had multi-lobular and mixed FAF patterns (p<0.001). Difference between FAF grade and central macular thickness and inner and outer segment (IS/OS) band disruption were statistically significant (p<0.001). IS/OS band disruption was primarily observed in patients with multi-lobular and mixed FAF patterns (p<0.041). Conclusion: Increased FAF grade and a mixed FAF pattern have statistically significant relation with the IS/OS band disruption ratio.

Correlations Between Fundus Autoflflourescence and Spectral-Domain Optical Coherence Tomography Measures in Patients with Diabetic Macular Edema