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ABS TRACT Objective: The aim of this study was to assess the repeatability and reliability of measurements obtained with Pentacam in keratoconic and cross-linked keratoconic eyes. Material and Methods: The subjects eligible for the study were composed of two groups: Keratoconus group and Collagen-cross-linking (CXL) group. All subjects underwent three consecutive corneal topography measurements using the Scheimpflug camera (Pentacam, Oculus, Germany). The time between each scan was, typically, about 1-2 min. The repeatability limits of the 3 repeated measurements were calculated. Reliability was assessed by an intraclass correlation coefficient (ICC). Results: This study comprised 36 eyes of 18 keratoconus patients and 28 eyes of 14 keratoconus patients cross-linking applied. All ICC values in both groups are more than 0.95. The repeatability limits are higher in CXL group than keratoconus group for all parameters except Q value, root mean square (RMS) of total and horizontal coma. The repeatability limits of K1, K2, Kmax and the thinnest corneal thickness (TCT) were 0.58 D, 0.64 D, 1.77 D and 14.3 μm in keratoconus group, respectively. The repeatability limits of K1, K2, Kmax and TCT were 1.39 D, 1.13 D, 2.06 D and 15.3 μm in CXL group, respectively. Conclusion: The higher repeatability limits of K1, K2 and Kmax in CXL group were interesting. These results show the need for studies with larger numbers evaluating the repeatability of Pentacam in keratoconus patients after cross-linking.

Does Corneal Collagen Cross-Linking Effect the Repeatability and Reliability of Scheimpflug Imaging in Keratoconus?