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ABS TRACT Ob jec ti ve: It is known that high fat di ets can ca u se en dot he li al dysfunc ti on, me di a ted by oxi da ti ve stress. In the pre sent study, we ai med to eva lu a te the vas cu lar res pon se of pol yun sa tu ra ted fatty acids (PU FA) and alp ha li po ic acid (ALA) on rat tho ra cic ar te ri es. Ma te ri al and Met hods: The pre sent study was con duc ted on ma le Wis tar al bi no rats. The n-6 and n-3 gro ups we re cre a ted from the rats that we re fed with pol yun sa tu ra ted fatty acid-rich di et, and 60% of the to tal ca lo ri e con tent com pri sed of fat. Furt her mo re, n-6/ALA and n-3/ALA gro ups we re cre a ted by the ad di ti on of strong an ti o xi dant alp ha li po ic acid in to the di et of n-6 and n-3 gro ups. The ef fects of di e tary n-6 and n-3 fatty acids and ALA on vas cu lar res pon se of the rat tho ra cic ar te ri es we re eva lu a ted in the iso la ted or gan bath. In ad di ti on, the ef fects of n-6 and n-3 fatty acids and ALA on the vas cu lar morp ho logy we re eva l u a ted using his toc he mi cal met hods. On the ot her hand, the glu tat hi o ne le vels in the red blo od cells we re com pa red bet we en n-6, n-3, n-6/ALA, and n-3/ALA gro ups. Re sults: We fo und dec re a sed en dot he li um de pen dent re la xa ti on and in cre a sed oxi da ti ve stress in n-6 and n-3 gro ups. Tre at ment with ALA im pro ved en dot he li um-de pen dent re la xa ti on and oxi da ti ve stres, and pre ven ted the wor se ning of vas cu lar his to pat ho logy. Conc lu si on: The re sults in di ca te that a high PU FA di et ca u sed en dot he li al dysfunc ti on by in cre a sing oxi da ti ve stress. Be si des, di e tary to tal amo unt of PU FA se ems to be mo re im por tant than n-6/n-3 ra ti o for car di o vas cu lar pro tec ti on.

Effect of Altering Dietary N-6:N-3 Pufa Ratio on Vascular Responsiveness in the Rat Thoracic Aorta