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Objective: We aimed to study the use of thrombin generation assay (TGA) test in patients diagnosed with recurrent abortus (RA) and with no pathological findings except thrombophilia. Material and Methods: A total of 125 women who presented to the Erciyes University (ERU) Medical School Department of Obstetrics and Gynecology were included in the study. Patients diagnosed with recurrent abortus (RA) comprised the study group (n=100) and healthy subjects without RA were considered the control group (n=25). The study group was divided into two subgroups as thrombophilia positive or thrombophilia negative according to their thrombophilia results. The women included in the control group were selected by random sampling among women who gave healthy births. Blood samples were drawn from the women in both groups for TGA, which is a defined test to analyse thrombophilia factors and coagulation. TGA analyses were run in the Haematology and Genetics Laboratory of ERU. Results: The study included 51 thrombophilia positive and 49 thrombophilia negative patients. In addition, 2 out of 25 women in the control group were thrombophilia positive. The thrombophilia positive group had the highest scores for endogenous thrombin potential (ETP) values, which is the most significant parameter in TGA tests; however, there was no significant difference between the thrombophilia negative group and the control group. A significant difference was detected between women with RA and the control group regarding the length of lag time, time to peak, and start tail. TGA is suggested to identify patients with RA who are thrombophilia positive independently from thrombophilia markers with a sensitivity of 96% (95% confidence interval-CI 86.5-99.4) and a specificity of 96% (95% CI 79.6-99.3). Conclusion: This study suggested for the first time in the literature that the TGA test, which is recently used to analyse coagulation may be used as an effective, sensitive and independent indicator to screeen patients with RA.

The Significance of Thrombin Generation Test in Recurrent Early Pregnancy Loss