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Objective: Paraoxonase 1 (PON1) was suggested to lower the risk of coronary artery disease (CAD) by preventing high-density lipoprotein-cholesterol (HDL-C) and low-density lipopro - tein-cholesterol (LDL-C) oxidation during atherosclerotic process. The relation between PON1 ac - tivity and CAD has been attributed to polymorphisms in the gene coding for this enzyme. The PON1 gene has two common polymorphisms, which lead to a leucine →methionine substitution at position 55 (PON55) and a glutamine →arginine substitution at position 192 (PON192), have been defined as the molecular basis of interindividual variability in PON activity. The aim of this study was to in - vestigate the frequency of PON55 and PON192 polymorphisms in Turkish patients with CAD and to determine whether this polymorphism was effective on plasma lipid levels. Material and Meth- ods: One hundred and thirty-five angiographically-defined CAD patients and 110 healthy controls were screened for the PON55 and PON192 genotypes and plasma lipids. Results: The frequency of PON55 MM genotype was significantly higher in the CAD patients than in the controls. The fre - quencies of PON192 genotypes were similar among CAD patients and controls. Both for PON55 and PON192 genotypes the HDL-C levels of CAD patients were significantly lower than in the corre - sponding controls. The severity of CAD was not associated with either the PON55 or the PON192 genotype. Conclusion: PON55 and PON192 genotypes are not useful markers for the estimation of either cardiovascular risk or the severity of coronary artery disease in the Turkish population.

Distribution of Pon L/M55 and Q/R192 Genotypes in Turkish Patients with Angiographically-Defined Coronary Artery Disease: Effects on Serum Lipids