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Objective: Genetic, hormonal, environmental factors and many infectious agents are thought to play role in the etiology of rheumatoid arthritis (RA). In this study, we aimed to investigate the role of Parvovirus B19 in etiology of RA and systemic lupus erythematosus (SLE). Material and Methods: Eighty-seven RA and 50 SLE patients diagnosed according to 1987 American College of Rheumatology (ACR) criteria and applied to Eskisehir Osmangazi University Medical Faculty, Internal Medicine Department, Division of Rheumatology between January 2007-January 2008, and a control group of 50 healthy blood donors were included in the study. In serum samples, Parvovirus B19 IgM, IgG (Focus Diagnostics Cypress, USA) were investigated by ELISA method. Genome presence and viral load were investigated by quantitative real-time polymerase chain reaction with Parvovirus B19 RG PCR kit (Qiagen, USA). The results were evaluated statistically by SPSS 20.0 program. Results: There was no significant difference between RA, SLE and healthy control groups in terms of Parvovirus B19 IgM (p=1.000). When Parvovirus B19 IgG positivity rate was considered, there was no difference between RA and SLE groups (p=0.277). Although there was no difference between RA and control groups (p=0.133), Parvovirus B19 IgG positivity rate was significantly higher in SLE group compared to the control group (p=0.016). Parvovirus B19-DNA was negative in all groups. Conclusion: We could not show any correlation between Parvovirus B19 and RA etiopathogenesis, there could be a relation between Parvovirus B19 and SLE etiopathogenesis. It is concluded that multicenter systematic investigations examining also synovial tissue and fluid samples are needed.

Investigation of the Etiologic Role of Parvovirus B19 by Immunologic and Molecular Methods in Rheumatoid Arthritis and Systemic Lupus Erythematosus