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ABS TRACT Ob jec ti ve: Beh cet’s di se a se (BD) is a chro nic, re cur rent, inf lam ma tory di se a se. CD19+CD5+ B cells are cur rently de fi ned as B1 cells and they pro du ce pol yre ac ti ve an ti bo di es. CD20+CD38 low B cells can ca u se en dot he li al cell ad he si on and are res pon sib le for spe ci fic an ti body synthe sis. The aim of this study was to in ves ti ga te the pre sen ce of CD19+CD5+ B cells and B cells con ta i ning CD20+CD38 low mo le cu le, which plays a ro le in B cell dif fe ren ti a ti on and ac ti va ti on. Mo re o ver, the ra ti o of the se cells in BD pa ti ents was al so eva lu a ted. Ma te ri al and Met hods: In this study, 20 BD pa ti ents and 20 he althy con trol sub jects we re com pa red. Blo od samp les of the pa ti ents and the con trol gro up we re stained with stan dard pro ce du re using CD3, CD19, CD20, CD5, CD38 mo noc lo nal an ti bo di es with flow cyto met ric met hod, and B lymphocy te sub gro ups we re eva lu a ted. Re sults: The re we re no sig ni fi cant dif fe ren ces bet we en to tal T and B lymphocy te ra ti os of two gro ups. Ho we ver, CD19+CD5+ B lymphocy tes and CD20+CD38 low prep las mab lasts we re sig ni fi cantly hig her in BD pa ti ents com pa red to the con trol gro up. Conc lu si on: It was de ter mi na ted that high le vels of CD20+CD38low and CD19+CD5+ B lymphocy tes in BD con cerns the pos sib le ro le of hu mo ral im mu nity or for ce of T cell in de pen dent res pon se. On the ot her hand, im me di a te dif fe ren ti a ti on of IgM pro du cing cells in di ca tes B cell ac ti va ti on and all the ot hers sup port the pos sib le ro le of CD38 in the eti o logy of vas cu li tis, which is the unc han ge ab le cha rac te ris tic and the ba sis of de fi ning BD as an au to inf lam ma tory di se a se.

Evaluation of CD19+CD5+ B (B1) Lymphocytes and CD2 + CD38 Low Preplasmablast Cells in Patients with Behçet’s Disease