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ABS TRACT Ob jec ti ve: The pur po se of our study is to in ves ti ga te the ef fect of pho tot he rapy on lymphocy te sub sets in the tre at ment of hyper bi li ru bi ne mi a in ne o na tes. Ma te ri al and Met hods: Twenty two term in fants as the study gro up and 25 term in fants as the con trol gro up we re hos pi ta li zed. Lymphocy te sub sets le vels we re in ves ti ga ted in blo od samp les du ring hos pi ta li za ti on in all in fants. Ho we ver, sub sets le vels we re in ves ti ga ted be fo re and eight ho urs af ter the pho tot he rapy, and on ce aga in af ter 48 ho urs in 16 in fants in the study gro up. Re sults: The lymphocy te co unt of in fants in the study and con trol gro ups we re fo und si mi lar, as well as the lymphocy te sub sets ra ti os. Apart from CD4+ lymphocy te co unt of the study gro up eight ho urs af ter the pho tot he rapy, any sig ni fi cant chan ge was not ob ser ved in lymphocy te sub sets. Ho we ver, sig ni fi cant in cre a se was de ter mi ned in CD4+ ra ti os af ter pho tot he rapy (p< 0.05). Any sig ni fi cant chan ge was not de ter mi ned in lymphocy te co unt and lymphocy te sub sets 48 ho urs af ter pho tot he rapy (p> 0.05). Conc lu si on: Apart from CD4+ count eight ho urs af ter pho tot he rapy, any ef fect was not de ter mi ned on the who le T-lymphocy te pro fi le af ter 48 ho urs. The re fo re, we as su me that the pos sib le ef fects of pho tot he rapy on the im mu ne system is not di rectly re la ted to the ef fects on T-lymphocy tes. The in cre a se in CD4+ which ap pe ars eight ho urs af ter pho tot he rapy re qu i res mo re de ta i led stu di es re gar ding the ef fect of pho tot he rapy on the im mu ne system.

The Effect of Phototherapy on the Lymphocyte Subsets in Newborn