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ABS TRACT Ob jec ti ve: Esc he ric hi a co li stra ins are the most com mon pat ho gens of uri nary tract in fec ti ons (UTI) and are ca pab le of pro du cing “ex ten ded spec trum be ta-lac ta ma se s” (ESBL). Sin ce high cip rof lo xa cin re sis tan ce has be en emer ging re cently among E.co li stra ins, this study is ai med to in ves ti ga te ESBL pro duc ti on and an ti bi o tic re sis tan ce pat tern inc lu ding cip rof lo xa cin, in 615 E.co li stra ins iso la ted from comp li ca ted and un comp li ca ted UTIs and dif fe ren ces bet we en two gro ups. Ma te ri al and Met hods: The an ti mic ro bi al sus cep ti bi lity tes ting for cip rof lo xa cin, tri met hop rim-sul fa met ho xa zo le, amo xi cil li ne-cla vu la na te, ami ka cin, pi pe ra cil li ne-ta zo bac tam and imi pe nem/me ro pe nem was per for med using Kirby-Ba u er disc dif fu si on met hod ac cor ding to Cli ni cal and La bo ra tory Stan dards Ins ti tu te (CLSI) rules. ESBL pre sen ce was in ves ti ga ted with do ub le disc dif fu si on met hod. An ti bi o tic sus cep ti bi li ti es of comp li ca ted and un comp li ca ted gro up with UTI we re com pa red sta tis ti cally using Fis her’s chi squ a re test. Re sults: E.co li stra ins we re iso la ted from 333 of 2458 pa ti ents with un comp li ca ted UTI and 282 of 2098 pa ti ents with comp li ca ted UTI. ESBL pre sen ce was in 13% and 20%, and cip rof lo xa cin re sis tan ce was 38% and 46% in un comp li ca ted and comp li ca ted gro ups, res pec ti vely. ESBL pre s en ce in cip rof lo xa cin re sis tan ce stra ins was 25% in un comp li ca ted gro up and 40% in comp li ca ted gro up. ESBL ra ti o in cip rof lo xa cin-sus cep tib le stra ins was 4% in both gro ups. Sta tis ti cally, ESBL pro duc ti on in cip rof lo xa cin re sis tan ce stra ins was hig her in the comp li ca ted gro up (p< 0.05). Conc lu si on: An ti bi o tic re sis tan ce in pat ho gens which are res pon sib le from UTIs is emer ging worl dwi de. We fo und that ESBL pro duc ti on in cip rof lo xa cin re sis tant E.co li stra ins was sig ni fi cantly hig her in the comp li ca ted gro up. This may re sult from mi su se and in ju di ci o us use of an ti mic ro bi als, es pe ci ally cip rof lo xa cin. No wa days, ESBL pro du cing mul tid rug re sis tant E.co li stra ins are in com mu nity as a new chal len ge emer ged for cli ni ci ans to over co me.

Antimicrobial Resistance of 615 Escherichia coli Isolated from Complicated and Non-Complicated Urinary Tract Infections