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ABS TRACT Ob jec ti ve: To eva lu a te re ti nal ner ve fi ber la yer (RNFL) thick ness chan ges of type 1 dia be tes mel li tus (DM) pa ti ents with and wit ho ut di a be tic re ti no pathy (DR). Ma te ri al and Met hods: One hun dred-eigh te en pa ti ents with type 1 DM and 49 age-matc hed con trol sub jects we re en rol led in the study. Ni net y e ight of 118 di a be tic pa ti ents with DR we re as sig ned as gro up 1 and the re ma i ning 20 pa ti ents wit ho ut DR we re la be led as gro up 20 (n= 98). The RNFL thick ness of all subjects we re me a su red using op ti cal co he ren ce to mog raphy (OCT). Re sults: The study inc lu ded 118 type 1 DM pa ti ents with a me an age of 18.77±8.80 ye ars. The me an age of 49 sub jects in the control gro up was 18.71 ± 5.72 (ran ge 7-40) ye ars.The me an RNFL thick ness was 103.79 ± 6.45 μm in the con trol gro up, 100.00 ± 11.93 μm in gro up 1 and 85.59 ± 19.81 μm in gro up 2. The dec re a se in gro up 2 was fo und sta tis ti cally sig ni fi cant (p< 0.001). The me an RNFL thick ness in the su pe ri or, na sal, in fe ri or and tem po ral qu ad rants we re less in gro up 1 com pa red to con trols, ho we ver this da ta was not sta tis ti cally sig ni fi cant (p= 0.274, p= 0.149, p= 0326, p= 0783, res pec ti vely). In gro up 2, the RNFL thick ness re ve a led a sta tis ti cally sig ni fi cant dec re a se in all qu ad rants (p< 0.001) ex cept tem po ral qu ad rant (p= 0.396). The me an du ra ti on of DM was sig ni fi cantly lon ger in gro up 2 (153.80 ± 70.35) com pa red to gro up 1 (60.76 ± 50.41 months) (p< 0.001). However, the re was no cor re la ti on bet we en the RNFL thick ness and the du ra ti on of DM. Conc lu si on: The RNFL thickness of pa ti ents with type 1 DM was fo und less com pa red to con trol sub jects. This was mo re pro mi nent in pa ti ents with es tab lis hed re ti no pathy (gro up 2). The se fin dings sug ges ted that the RNFL thick ness me a su re ment with the aid of OCT may be used as an ad junc ti ve di ag nos tic to ol for early di ag no sis of DR.

Evaluation of Retinal Nerve Fiber Layer Thickness with Optical Coherence Tomography in Type 1 Diabetes Mellitus Patients