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ABS TRACT Ob jec ti ve: The ef fec ti vity of re mi fen ta nil and li do ca i ne com bi na ti on on the in jec ti on pa in with 1% pro po fol was re por ted pre vi o usly. Ho we ver, this fin ding has not be en in ves ti ga ted with dif fe rent pro po fol con cen tra ti ons. In this pros pec ti ve, ran do mi zed, do ub le-blind tri al, we ai med to com pa re the ef fect of li do ca i ne on the in jec ti on pa in of 1% or 2% pro po fol in pa ti ents re ce i ving re mi fen ta nil. Ma te ri al and Met hods: One hun dred pa ti ents un der go ing ear-no sethro at sur gery we re ran domly as sig ned into fo ur gro ups (n= 25 each). Fol lo wing 0.5 μg/kg/min re mi fen ta nil, pa ti ents in Gro up 1 and Gro up 2 re ce i ved 1 mg.kg-1 1% or 2% pro po fol the mi xed with 2 mL of sa li ne, res pec ti vely. Pa ti ents in Gro up 3 and Gro up 4 re ce i ved 1 mg.kg-1 1% or 2% pro po fol mi xed with 2 mL of 2% li do ca i ne af ter 0.5 μg kg-1 min-1 re mi fen ta nil. Pa in du ring the injec ti on of pro po fol was as ses sed on a fo ur-po int sca le (0= no ne, 1= mild, 2= mo de ra te, 3= se ve re) Re sults: The in ci den ce of no ne-mild pa in on in jec ti on of 1% pro po fol was sig ni fi cantly lo wer in Gro up 1 (56%) com pa red to Gro up 3 (100%) (p= 0.00017). This fin ding was al so seen bet we en Gro up 2 (36%) and Gro up 4 (72%) (p= 0.010). Ho we ver, the num ber of pa ti ents suf fe ring from the in jec ti on pa in was sig ni fi cantly gre a ter in Gro up 4 com pa red to Gro up 3 (p= 0.004). Conc lu si on: Li do ca i ne 2% 2 mL mi xed with pro po fol comp le tely abo lis hed mo de ra te-se ve re pa in in du ced by 1% pro po fol in pa ti ents who we re gi ven 0.5 μg/kg/min re mi fen ta nil. Ho we ver, so me pa ti ents still suf fe red from in jec ti on pa in ca u sed by 2% pro po fol in spi te of the com bi ned ef fect of li do ca i ne and re mi fen ta nil.

The Effect of Lidocaine on Injection Pain of Different Propofol Concentrations in Patients Receiving Remifentanil