English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

ABS TRACT Ob jec ti ve: Pe ro xi so me pro li fe ra tor-ac ti va ted re cep tor gam ma (PPARγ), li pids, li pop ro te ins, and adi po ki nes ha ve re cently be en shown to be as so ci a ted with psychi at ric di se a ses. Our ma jor aim is to in ves ti ga te the con tri bu ti on of the PPARγ ge ne poly morp hism, adi po ki nes, li pids, and li pop ro te ins to the de ve lop ment of ma jor dep res si on. Ma te ri al and Met hods: The fre qu ency of Pro12Ala in exon 2 and C478T in exon 6 of the PPARγ ge ne, li pids and adi po ki nes in ma jor dep res si on (n = 78) and con trol sub jects (n= 64) we re analy zed. Ge noty pes of PPARγ ge ne poly morp hisms we re exa mi ned. Se rum lep tin, adi po nec tin, and re sis tin we re stu di ed by enz yme-lin ked im mu no sor bent as say (ELI SA). Se rum apo A1, apo B, and Lp(a) le vels we re de ter mi ned by im mu no nep he lo metry. Se rum to tal cho les te rol, trigl yce ri de, HDL-cho les te rol and LDL-cho les te rol le vels we re analy zed by enz yma tic met hods. Re sults: The ge noty pes of exon 2 and exon 6 dis tri bu ti on did not dif fer bet we en the con trol sub jects and patients with ma jor dep res si on. Fre qu en ci es of ge noty pes of Pro12Ala, and Ala12Ala in exon 2 in over we ight and obe se pa ti ents with ma jor dep res si on we re hig her than tho se of over we ight and obe se con trols. C478T poly morp hism was hig hest in over we ight and obe se pa ti ents with ma jor dep res si on. Pro12Ala and Ala12Ala ge noty pes in exon 2 of PPARγ ge ne in pa ti ents we re fo und to be as so ci a ted with trigl yce ri de and HDL-cho les te rol. The re we re sig ni fi cant dif fe ren ces re gar ding glu co se, to tal cho les te rol, LDL-cho les te rol, apo B, Lp(a), adi po nec tin and re sis tin le vels bet we en pa ti ent and con trol sub jects. Conc lu si on: PPARγ exon ge ne poly morp hisms, al te ra ti ons in li pid pro fi le and adi po ki nes may be as so ci a ted with the de ve lop ment of ma jor dep res si on.

türkiye klinikleri tıp bilimleri dergisi

The Relationship Between the Peroxisome Proliferator-Activated Receptor Gamma 2 Gene Polymorphism, Lipids and Adipokines in Patients with Major Depression