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Dipyrone is a potent analgesic and antipyretic drug that has been used clinically for more than 80 years. In some parts of the world, it has been banned because of its association with agranulocytosis. We reported two different cases, presenting with rare but life-threatening adverse effects of dipyrone. First case was a 63-year-old woman that presented to the emergency department with fever. She had developed neutropenia after taking a 500 mg oral dipyrone tablet and follow - ing further evaluation was diagnosed with dipyrone-induced agranulocytosis. Second case was a 70-year-old man who presented to the emergency department with diffuse erythematous skin rash after dipyrone injection and was diagnosed with toxic epidermal necrolysis associated with dipy - rone. The balance between the benefit and harm is particularly important. Nevertheless, agranu - locytosis is not the only life-threatening risk with dipyrone use and limiting the discussion of risks of dipyrone to agranulocytosis leads to an underestimation of the dangers of the drug.

Dipyrone, Great Killer or Innocent as Any Drug: Two Case Reports Presenting Rare and Life-Threatening Adverse Effects of Dipyrone