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ABS TRACT Objective: Aberrant Wnt signaling pathway activation and stabilization of β-catenin protein is associated with tumorigenesis and human breast tumors. We have examined β-catenin, cyclin D1, sFRP1 and sFRP2 expressions in the breast cancer and effects of these factors on prognostic parameters in patients with breast cancer. Material and Methods: One hundred and seventeen consecutive female malignant breast tumor patients were enrolled into the study. The mean age was 50.0 (±18.0) years. Immunohistochemical staining method was used to investigate the stability and location of β-catenin, expressions of sFRP1 and sFRP2 and cyclin D1 proteins. Results: Percentage expression of β-catenin, siklin D1, sFRP1 and sFRP2 were 60.0 ± 55.0, 40.0 ± 64.0, 15.0±48.0 and 25.0 ± 53.0, respectively. Menopausal status, progesterone receptor positivity, lymph node involvement and TNM staging did not show any statistically significant relation with the expression of β-catenin, cyclin D1, sFRP1 or sFRP2. However, significantly higher percentages of expression of cyclin D1 were determined in patients showing estrogen receptor positivity and cerbB-2 over-expression (p= 0.008). Additionally β–catenin expression was significantly higher only in the p53-positive group (p= 0.03). None of the parameters used in this study showed a significant effect on clinicopathological prognostic parameters. Conclusion: These findings suggested that expression levels and staining results of β-catenin, cyclinD1, sFRP1 and sFRP2 in tumor cells were independent from histological grade, lymph node involvement, and TNM stage. We concluded that β-catenin accumulation, cyclin D1, sFRP1 and sFRP2 expressions were not affected by the Wnt signaling pathway.

β-Catenin Stability, Cyclin D1 and Frizzled Proteins Expression in Human Breast Cancer and Their Relation with the Prognosis