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ABS TRACT Ob jec ti ve: Bo ne grafts ha ve be en wi dely used in os se o us de fects in me di ci ne and dentistry (e.g. pe ri o don to logy, imp lan to logy). This study aims to as sess bo ne and tis su e res pon se to a xe nog raft (Uni lab Sur gi bo ne) af ter the first and third month of imp lan ta ti on and its cyto to xi city in vit ro. Ma te ri al and Met hods: Fif te en rats, each of which ha ving a 5 mm cri ti cal-si ze, symmet ri cal, cir cu lar de fects in the cor pus of the man dib le we re rec ru i ted. The ex pe ri men tal de fects we re fil led with the bi o ma te ri al whe re as de fects on the op po si te si de we re used as con trols (sham-ope ra ted gro up). Af ter his to lo gi cal fol low-up, se ri al sec ti ons we re pre pa red for eva lu a ti on un der light mic ros co pe. The cyto to xi city of xe nog raft was exa mi ned in vit ro. Re sult: Xe nog rafts did not show any cyto to xi city for the cells. The re was no cal lus for ma ti on in the imp lan ta ti on si te at the first and third months, and Uni lab Sur gi bo ne ma te ri al was sur ro un ded with fib ro us tis su e. Den se col la ge no us tis su e was ob ser ved in the con trol si te at the first and third months. Conc lu si on: Alt ho ugh the re was no evi den ce of bo ne bu il ding, the bi o ma te ri al se ems bi o com pa tib le and can be con si de red as a spa ce fil ler for such app li ca ti ons in den tistry.

Evaluation of the Bone Repair Capacity and the Cytotoxic Properties of a Particular Xenograft: An Experimental Study in Rats