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ABS TRACT Ob jec ti ve: The aim of this study was to eva lu a te and com pa re in vit ro bi o com pa ti bi lity and poly(glyco lic acid) (PGA) and poly(lac ti de-co-glyco li de acid) (PLGA) on tu mo ri ge nic and non-tu mo ri ge nic ma tu re sphe ro ids. Ma te ri al and Met hods: This is an in vit ro ex pe ri men tal study. Tu mo ri ge nic (C6 gli o ma, SH-SY5Y, MDAH2774, MCF-7) and non-tu mo ri ge nic cells [CRL11372, pri mary os te ob lasts (MCPO)] as well as the ir ma tu re sphe ro ids we re cul tu red alo ne as a con trol gro up as well as in combination with PGA and PLGA. To tal cell num bers, bro mo de ox yu ri di ne la be ling in dex (BrDU-LI), apop to sis, morp ho logy, and ul tras truc tu re we re eva lu a ted. Re sults: PGA and PLGA sig ni fi cantly dec re a sed the number of SHSY5Y and C6 gli o ma cells; MDAH 2774 cells al so dec re a sed, but not sig ni fi cantly (p> 0.05). Low BrDULI (p< 0.05) with a high le vel of apop to sis (p< 0.05) at C6 gli o ma and a high le vel of BrDU-LI (p< 0.05) with a low le vel of apop to sis at MDAH2774 (p< 0.01) we re noted. The se bi o poly mers mostly dec re a sed the num ber of CRL-11372 cells (p< 0.05), but in di ca ted an in cre a sed apop to sis (p< 0.01) and sig ni fi cant BrDULI (p< 0.05). Bi o poly mers in du ced chro ma tin con den sa ti on (typi cal apop to tic ul tras truc tu re) and va cu o li za ti on pri ma rily at SH-SY5Y sphe ro ids but ra rely at MDAH-2774 sphe ro ids. This apop to tic ul tras tuc tu re was most of ten ob ser ved at MCPO sphe ro ids. PLGA and PGA in du ced si mi lar BrDU-LI dec re a ses among tu mo ri ge nic sphe ro ids (p< 0.05), alt ho ugh this dec re a se was gre a ter at MCF-7 (p< 0.05) in the PGA gro up. PGA pri ma rily dec re a sed BrDU-LI at CRL 11372 (p< 0.05), alt ho ugh the dec re a se was al most iden ti cal to that at MCPO for the two bi o poly mers (p< 0.05). A sig ni fi cant at tach ment af fi nity was de ter mi ned at MDAH -2774 and C6 gli o ma sphe ro ids. Conc lu si on: This study de mons tra ted the bi o com pa ti bi lity of PGA and PLGA at ma tu re sphe ro ids of tu mo ri ge nic and non-tu mo ri ge nic cell li nes, which chan ged accor ding to the cell type.

türkiye klinikleri tıp bilimleri dergisi

Evaluation and Comparison of In Vitro Biocompatibility of Poly (Glycolic Acid) and Poly (Lactide-Co-Glycolide Acid) on Mature Spheroids of Tumorigenic and Non-Tumorigenic Cell Lines