English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

ABS TRACT Ob jec ti ve: Fre e ra di cal pro duc ti on is imp li ca ted in the pat ho ge ne sis of di a be tes mel li tus, in which se ve ral path ways and dif fe rent mec ha nisms are shown to in vol ve in the pat hoph ysi o logy of the comp li ca ti ons. Thro ugh the ad mi nis tra ti on of ni co ti na mi de(NA) and strep to zo to cin(STZ), a mo del of hu man type II di a be tes can be in du ced in rats. The aim of this study was to de ter mi ne the ef fects of Ste vi a re ba u di a na (SrB) and L-NNA (N-nit ro-L-ar gi ni ne) in the for ma ti on of fre e ra di cals in STZ-NA in du ced type II di a be tic rats. Ma te ri al and Met hods: In this study, rats we re tre a ted with SrB and L-NNA 5-8 we eks af ter the in duc ti on of di a be tes. The le vels of glu tat hi o ne pe ro xi da se (GPx), su pe ro xi de dis mu ta se (SOD), ca ta la se (CAT) and ma lon di al dehy de (MDA) we re de ter mi ned in the li ver ho mo ge na te and eryt hrocy te he moly sa te. The nit ric oxi de syntha se (NOS) le vels we re al so me a su red in the li ver ho mo ge na te and se rum. To study the his to lo gi cal chan ges in di a be tes, the li ver tis su e samp les sta i ned with he ma toxy lein-eo sin and we re in ves ti ga ted under light mic ros co pe. Re sults: Alt ho ugh fas ting and post pran di al blo od su gar le vels we re high in di a be tic gro ups, blo od su gar le vels we re sig ni fi cantly re du ced in di a be tic tre a ted gro ups. Whi le the erythrocyte MDA le vels of ste vi a-tre a ted di a be tic gro up dec re a sed, li pid pe ro xi da ti on in cre a sed with L-NNA tre at ment in both con trol and di a be tic gro ups. The re was no sig ni fi cant diffe ren ce for the tis su e CAT, NOS, and eryt hrocy te SOD and CAT ac ti vi ti es between. Li ver samp les in con trol gro up had a nor mal struc tu re. Nor mal his to lo gi cal ar ran ge ment was no ti ced in the li vers of con trol gro up. In he pa tocy tes of the di a be tic con trol gro up, nec ro tic cells with pycno tic nuc le us and eo si noph ylic cytop lasm as well as si nu so i dal di la ta ti on were se en. The he pa tocy te struc tu re was mo re pro tec ted in di a be tic LNNA gro up than in di a be tic gro up. The ma xi mum pro tec ti on was se en in he pa tocy tes of di a be tic ste vi a L-NNA gro up. Conc lu si on: SrB and L-NNA re du ced blo od glu co se le vels in di a be tic rats and had so me be ne fi ci al ef fects on oxi da ti ve and his to lo gi cal chan ges. Ho we ver, a NOS in hi bi tor, L-NNA was less ef fec ti ve than SrB tre at ment in type II di a be tes.

türkiye klinikleri tıp bilimleri dergisi

Antioxidant and Free Radical-Scavenging Properties of Stevia rebaudiana (Bertoni) Extracts and L-NNA in Streptozotocine-Nicotinamide Induced Diabetic Rat Liver