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ABS TRACT Ob jec ti ve: Ef fec ti vity and sa fety of azat hi op ri ne in the tre at ment of inf lam ma tory bo wel di se a se ha ve be en pro ved and ci ted in many ar tic les. Ob jec ti ve of this study is to eva lu a te the ef fi cacy and si de ef fects of azat hi op ri ne par ti cu larly in the long term tre at ment and post sur gi cal proph yla xis of Crohn’s di se a se in Tur kish pa ti ents with inf lam ma tory bo wel di se a se. Ma te ri al and Met hods: Pa ti ents tre a ted with azat hi op ri ne we re en rol led in this study and the ef ficacy of azat hi op ri ne was as ses sed with Tru e lo ve-Witts and Crohn’s Di se a se Ac ti vity In de xes, retrospectively. Re sults: A total of 122 pa ti ents tre a ted with azat hi op ri ne with a me di an du ra ti on of 24 months, inc lu ding 109 pa ti ents with Crohn’s di se a se and 13 with ul ce ra ti ve co li tis, we re eva lu a ted. Res pon se (comp le te or par ti al re mis si on) was ob ser ved in 106 (98+8, 87%) of 122 pa ti ents. The me di an du ra ti on of re mis si on du ring the tre at ment was 21 months. Ad ver se ef fects we re ob ser ved in 16% (19/122) of our pa ti ents and mye lo to xi city was the most fre qu ent ad ver se ef fect seen in 6.6% (8/122) of the patients. Drug dis con ti nu a ti on ra te du e to si de ef fects was 9.8%. Ove rall res pon se (comp le te and par ti al re mis si on)was seen in 38 (36+2, 90.5%) out of 42 pa ti ents that had be en ta king azat hi op rin for mo re than fo ur ye ars with a me di an period of 60 months. The me di an of re mis si on du ra ti on in tho se pa ti ents that had si mi lar si de ef fects was 53 months. Cli ni cal re cur ren ce was se en in six of 31 pa ti ents tre a ted with azat hi op ri ne for post-sur gi cal proph yla xis in a me di an fol low-up of 42 months. Conc lu si on: Our study re-af fir med the sa fety and the ef fec ti ve ness of azat hi op ri ne in the tre at ment of inf lam ma tory bo wel di se a se, es pe ci ally for post-sur gi cal proph yla xis and the long term tre at ment.

Efficacy and Safety of Azathioprine Therapy in Turkish Patients with Inflammatory Bowel Disease: A Retrospective Long Term Follow Up Study