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ABS TRACT Ob jec ti ve: Pso ri a sis vul ga ris is a chro nic inf lam ma tory T-cell me di a ted im mu ne derma to sis cha rac te ri zed by a high epi der mal cell tur no ver, which re sults in a typi cal epi der mal hyperp la si a. The aim of this study is to show the cor re la ti on bet we en p53 pro te in ac cu mu la ti on that pro vi des epi der mal hyper pro li fe ra ti on and mast cell co unt in the pat ho ge ne sis of pso ri a sis vul ga ris. Ma te ri al and Met hods: In this study, punch bi op si es from 56 pso ri a sis ca ses ha ve be en eva lu a ted. The pre sen ce of mast cells in with me tac hro ma tic gra nu les are with 1% to lu i din blu e sta in so lu ti on has be en in ves ti ga ted. In ad di ti on, mast cells that show im mu no re ac ti ons to “mast cell trypta se ” an ti body ha ve be en ob ser ved and pro por ti on of p53 sta i ning in epi der mal ke ra ti nocy tes has be en de ter mi ned. Re sults: In pso ri a sis ca ses, mast cells co unt (me an) and pro por ti on of p53 sta i ning (me an) were 69.3 ± 21.5/mm2 and 602.3 ± 192.1 respectively, in the gro up wit ho ut any tre at ment (n: 20); 57.1 ± 27.5/mm2 and 373.1 ± 193.6 respectively in the gro up tre a ted with pso la ren plus UVA ra di a ti on (n: 36). In the con trol gro up, it was de mons tra ted that mast cells co unt was 74.6 ± 25.9/mm2 (me an) and pro por ti on of p53 sta i ning was 176.4 ± 109.2 (me an). No cor re la ti on has be en fo und bet we en mast cell co unt and pro por ti on of p53 sta i ning in pso ri a sis gro ups. Ho we ver, a mo de ra te cor re la ti on (r= 0.30 P< 0.05) has be en fo und bet we en mast cell co unt and pro por ti on of p53 sta i ning in the con trol gro up. Conc lu si on: Sin ce the cor re la ti on ob ta i ned bet we en mast cell num ber and pro por ti on of p53 sta i ning in the he althy skin was not observed pso ri a sis ca ses, it can be tho ught that the se va ri ab les ta ke part in different pathways of pathogenesis.

Mast Cells and p53 Expression in Psoriasis Vulgaris