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ABS TRACT Objective: Sur gi cally in du ced ne u ral ref lex res pon ses and en doc ri ne me ta bo lic ca ta bo lic res pon ses sho uld be al le vi a ted by ef fec ti ve pa in-re li e ving tech ni qu es and ne u ral bloc k. The aim of this study was to com pa re the ef fects of two dif fe rent lo cal anest he si a tech ni qu es on the stress res pon se du ring ab do mi nal hyste rec tomy. Material and Met hods: In this pros pec ti ve, rando mi zed study, 60 pa ti ents ad mit ted for be nign ute ri ne di se a ses we re di vi ded in to thre e gro ups; ge ne ral anest he si a alo ne (Gro up CO-gro up con trol); ge ne ral anest he si a plus 3 mL bu pi va ca i ne (0.5%) which was in jec ted in to the ro und and ute ro sac ral li ga ments (Gro up IN-gro up in fil tra ti on) bi la te rally, and ge ne ral anest he si a plus pel vic ca vity ir ri ga ti on with 40 mL bu pi va ca i ne (0.125%) (gro up IR-gro up ir ri ga ti on). The he art ra te, me an ar te ri al pres su re, plas ma glu co se and cor ti sol le vels we re re cor ded pe ri o pe ra ti vely. Re co very ti me was recorded and Nu me ri cal Ra ting Sca le for pa in was obtained 15 mi nu tes af ter ex tu ba ti on. Re sults: He art ra te was the hig hest in Gro up CO com pa red to the ot her gro ups fol lo wing the ute ri ne re mo val and at the pos to pe ra ti ve 15th mi nu te (P< 0.05). The plas ma cor ti sol le vel was the lo west in Gro up IN fol lo wing the ute ri ne re mo val and the hig hest in Gro up CO at the pos to pe ra ti ve 15th mi nu te (P< 0.05). Va lu es of Nu me ri cal Ra ting Sca le for pa in we re si mi lar among the gro ups (P> 0.05). Conc lu si ons: In ad di ti on to ge ne ral anest he si a, lo cal anest he tic ad mi nis tra ti on in to the ute ri ne li ga ments or the pel vic ca vity may be mo re ef fec ti ve in at te nu a ting the sur gi cal stress res pon se es pe ci ally in whom this stress res pon se wo uld be de le te ri o us.

Local Anesthetic Administration Into Uterine Ligaments or Pelvic Cavity to Attenuate Surgical Stress Response During Abdominal Hysterectomy