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ABS TRACT Ob jec ti ve: The aim of this study was to de mons tra te the ra di op ro tec ti ve ef fects of gink go bi lo ba (G. bi lo ba, EGb 761), pro bi o tic Sacc ha romy ces bo u lar di i (S. bo u lar di i) and N-acetylc yste i ne (NAC) on ra di a ti on-in du ced small in tes ti ne in jury vi a im mu no his toc he mi cal eva lu a ti on using pan cad he rin, a cell ad he si on mo le cu le. Ma te ri al and Met hods: A to tal of 48 fe ma le Wis tar al bi no rats we re di vi ded in to fi ve gro ups: ne ga ti ve and po si ti ve con trols, G. bi lo ba, S. Bo u lar di i and NAC gro ups. The ra di op ro tec ti ve agents we re star ted as twi ce per day by ga va ge re gi men the day be fo re the first ra di a ti on ex po su re. Ex ter nal ab do mi nal ra di ot he rapy, 5Gy/day, un der ge ne ral anest he si a was ad mi nis te red on fi ve con se cu ti ve days en ding up with fi ve frac ti ons in total (25Gy). Ra di op ro tec ti ve agent ad mi nis tra ti on was comp le ted to 14 days and the rats we re sac ri fi ced on the 15th day. Af ter ex trac ti on of the je ju num, tis su e morp ho logy, in teg rity and the num ber of vil li were eva lu a ted in H&E sta i ned sli des and pan cad he rin im mu no re ac ti ve cells we re eva lu a ted im mu no his toc he mi cally. Re sults: The dis rup ti on of mu co sal morp ho lo gi cal in teg rity, de ge ne ra ti ve spa ces and ede ma to us ca vi ti es we re ob ser ved af ter ra di a ti on-in du ced je ju num in jury. The con tri bu ti on of the ra di op ro tec ti ve ef fect of all agents were shown on tis su e in teg rity. Ho we ver, the most pro mi nent ef fect was no ted in the NAC gro up. In addition, the num bers of vil li and pan cad he rin im mu no re ac ti ve cells in the NAC gro up we re sig ni fi cantly higher than the ot her gro ups. Conc lu si on: NAC is a go od agent in pro tec ting aga inst and ame li o ra ting ad ver se ef fects of ra di ot he rapy in a rat mo del.

türkiye klinikleri tıp bilimleri dergisi

Immunohistochemical Evaluation of the Protective Effect of Ginkgo Biloba, Probiotic Saccharomyces Boulardii and N-Acetylcysteine on Radiation-Induced Small Intestine Injury