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ABS TRACT Ob jec ti ve: He li co bac ter pylo ri in fec ti on is a well-de fi ned risk fac tor for the de ve lop ment of gas tric ade no car ci no ma and mu co sa-as so ci a ted lympho id tis su e (MALT) lympho ma. Ho we ver, mec ha nisms of car ci no ge ne sis in He li co bac ter gas tri tis ne ed to be elu ci da ted. We ai med in this study to de ter mi ne the im mu no his toc he mi cal ex pres si ons of so me can cer-as so ci a ted ge nes, and to show dif fe ren ces bet we en He li co bac ter gas tri tis and He li co bac ter-ne ga ti ve gas tri tis. Ma te ri al and Met hods: Sixty-thre e en dos co pic bi opsy samp les we re se lec ted. The samp les com pri sed of nor mal gas tric mu co sa (20 samp les), He li co bac ter gas tri tis (22 samp les), and He li co bac ter-ne ga ti ve gas tri tis (21 samp les). Pa raf fin sec ti ons of samp les we re pro ces sed im mu no his toc he mi cally with so me sup pres sor ge nes (Rb, p53), pro to on co ge nes (EGFR, cyclin D1), and a he at shock pro te in, HSP 105. The ge ne ex pres si ons in both crypt epit he li a and lympho id in fil tra te we re eva lu a ted se pa ra tely. Re sults: In epit he li a; ex pres si ons of cyclin D1, p53, HSP 105, and EGFR we re hig her in Heli co bac ter-ne ga ti ve gas tri tis than in He li co bac ter gas tri tis (p< 0.0001). Im mu ne ex pres si on of HSP 105 in He li co bac ter gas tri tis was lo wer than in con trol gro up (p= 0.008) as well as in He li co bac ter-ne ga ti ve gas tri tis. Ho we ver, ex pres si on of Rb was hig her in He li co bac ter gas tri tis than in He li co bac ter-ne ga ti ve gas tri tis (p= 0.034). In lympho id in fil tra te; im mu ne re ac ti ons for p53 and cyclin D1 we re ne ga ti ve in all samp les. Ex pres si ons of Rb, EGFR, and HSP 105 in lympho id in fil tra te we re si mi lar to ex pres si ons in epit he li a for all gro ups. Conc lu si on: We can sug gest that de ve lop ment of gas tric can cer has a dif fe rent path way in He li co bac ter gas tri tis when compared to the one He li co bac ter-ne ga ti ve gas tri tis. In ad di ti on, dec re a se of he at shock pro te ins in He li co bac ter gas tri tis may le ad to sen si ti vity of crypt epit he li a and lympho id in fil tra te for car ci no ge nic mu ta ti ons.

Do Gene Expressions Differ Between Gastritis with and without Helicobacter pylori?