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ABS TRACT Ob jec ti ve: It is not known whet her in hi bi ti on of α1- ad re no re cep tor in a rat mo del of par ti al blad der out let obs truc ti on (BO O) ca u ses dec re a se in tu bu lar and glo me ru lar cell de ath by apop to sis and pre ven ti on of sub se qu ent inf lam ma ti on and fib ro sis. The aim of this study was to de mons tra te the re la ti ons hip bet we en apop to sis and do xa zo si n 1-ad re no cep tor an ta go nist) in rat kid neys da ma ged by par ti al BO O. Ma te ri al and Met hods: A to tal of 45 adult fe ma le Wis tar rats,with a me an weight of 250 g we re ran domly al lo ca ted to four ex pe ri men tal gro ups as: sham-ope ra ted rats (10 rats), sham-ope ra ted rats tre a ted with do xa zo sin (10 rats), par ti al BO O gro up (14 rats), and par ti al BO O gro up tre a ted with do xa zo sin (11 rats). Par ti al BO O was sur gi cally in du ced. De tec ti on of cell apop to sis was do ne by TU NEL as say. Re sults: This in ves ti ga ti on re ve a led in cre a sed apop to sis in both tu bu lar and glo me ru lar cells of rats with par ti al BO O. Furt her mo re, the re sults of this study de mons tra ted that do xa zo sin tre at ment of rats re du ced apop to sis in tu bu lar and glo me ru lar cells in both the con trols and the rats with par ti al BO O. Conc lu si on: We be li e ve that our observation of de c re a sed apop to sis in both tu bu lar and glo me ru lar cells of rats with par ti al BO O might be use ful to ga in new in sight in to the the ra pe u tic ef fect of do xa zo sin.

Beneficial Effect of Doxazosin on Renal Apoptosis After Partial Bladder Outlet Obstruction