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716 nterferon-alpha (IFN-α) is a natural glycoprotein produced by immune cells in response to viral infections, and it is widely used to treat chronic viral hepatitis.1 Multiple sclerosis (MS) is an autoimmune disorder characterized by demyelination in the central nervous system (CNS). Diagnosis of the disease is made according to the revised McDonald diagnostic criteria for MS based on clinical, magnetic resonance imaging (MRI) and laboratory findings.2 Although the cause of demyelination remains unknown, occasionally a theraupetic agent may promote an autoimmune process that attacks myelin. IFN-α associated MS has been reported in two chronic leukemia patients (CML) and one chronic hepatitis C patient.3,4 Optic neuritis is one of the presenting features of MS in about 20% of patiRetrobulbar Neuritis as the Initial Sign of Interferon-Alpha-Associated Multiple Sclerosis in a Chronic Hepatitis B Patient: Case Report