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ABS TRACT Ob jec ti ve: To eva lu a te the pre dic ti ve va lu e of ma xi mum ins pi ra tory pres su re (MIP) be si des ra pid and shal low bre at hing in dex (RSBI) in the we a ning of chro nic obs truc ti ve pul mo nary di se a se (COPD) pa ti ents. Ma te ri al and Met hods: Fifty-six COPD pa ti ents with acu te exa cer ba ti on and type II res pi ra tory fa i lu re re qu i ring in va si ve mec ha ni cal ven ti la ti on for mo re than 24 ho urs we re en rol led in this study. Ex tu ba ti on was plan ned if the pa ti ents to le ra ted pres su re support mo de for at le ast two ho urs and spon ta ne o us bre at hing du ring a 30 mi nu tes T-pi e ce tri al. Bre at hing fre qu ency, ex ha led ti dal vo lu me, ra pid and shal low bre at hing in dex (RSBI), mi nu te ven ti la ti on (Vmin), MIP and vi tal ca pa city me a su re ments we re re cor ded pri or to ex tu ba ti on. Pati ents we re di vi ded in to two gro ups ac cor ding to we a ning suc cess (WS) and fa i lu re. WS was defi ned as 48 ho urs of in de pen den ce from mec ha ni cal ven ti la ti on af ter ex tu ba ti on. Re sults: Alt ho ugh RSBI va lu es bet we en two gro ups we re not sig ni fi cantly dif fe rent, the re we re sta tis ti cally sig ni fi cant dif fe ren ces bet we en the two gro ups in terms of MIP (30 vs 18 cmH2O; p= 0.008) and Vmin (10.40 vs 8.25; p= 0.032). Pa ti ents with a MIP va lu e gre a ter than or equ al to 25 cm H2O had gre a ter WS when com pa red to tho se with va lu es lo wer than 25 cm H2O. Conc lu si on: RSBI alo ne se ems not re li ab le eno ugh to pre dict we a ning out co me in COPD pa ti ents with type II res pi ra tory fa i lu re du e to acu te exa cer ba ti on. Sup por ted with MIP, bet ter re sults may be ac hi e ved to pre dict we a ning out co me.

Maximum Inspiratory Pressure: Can it Be A Helpful Parameter for Predicting Successful Weaning in Chronic Obstructive Pulmonary Disease Patients?