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The most re cent in for ma ti on on the pat ho ge ne sis of CU sug gests that many ca ses ha ve an un derl ying au to im mu ne di se a se. Ten to forty per cent of CU pa ti ents ha ve im mu nog lo bu lin (Ig) G-struc tu re an ti bo di es aga inst IgE or the alp ha cha in of high-af fi nity IgE re cep tors in the ir se rum.1-3 Ad di ti o nally, the facts that high le vels of au to an ti bo di es such as an ti-TG and an tiTPO in CIU patients, and their res ponse to im mu no sup pres si ve tre at ments such as cyclos po ri ne A at trac ted at ten ti on to au to im mu nity’s im por tan ce in CU’s eti o logy.4-7

Is Chronic Urticaria an Autoimmune Disease?: Letter to the Editor