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ABS TRACT Ob jec ti ve: Nons te ro i dal an ti-inf lam ma tory drugs (NSA ID) are among the most wi dely pres cri bed agents in os te o art hri tis pa ti ents, and may le ad to im por tant si de-ef fects which in cre a se the risk of hos pi ta li za ti on and de ath. Trans der mal ad mi nis tra ti on of NSA IDs can pro vi de re li ef of pa in lo cally with re la ti vely less si de ef fects. This study was ai med to eva lu a te the ef fi cacy of a sing le ad mi nis tra ti on of 40 mg trans der mal flur bip ro fen on pa in and on strength of qu ad ri ceps and hams tring musc les in pa ti ents with kne e os te o art hri tis. Ma te ri al and Met hods: This study is a do ub le blind, pla ce bo-con trol led cross-over pre li mi nary study. Trans der mal flur bip ro fen and pla ce bo patc hes we re ad mi nis te red to the 24 pa ti ents with kne e os te o art hri tis. Kne e pa in was eva lu a ted using a vi su al ana log sca le (VAS) and the strength of qu ad ri ceps and hams tring musc les using an isoki ne tic dyna mo me ter. Re sults: Me an VAS sco res re du ced from 5.3 ± 1.7 to 4.7 ± 1.6 (p= 0.88) af ter pla ce bo ad mi nis tra ti on, and from 5.4 ± 1.9 to 3.9 ± 1.7 (p= 0.04) fol lo wing flur bip ro fen ad mi nis tra ti on. Pe ak tor qu e and to tal work va lu es of fle xor and ex ten sor musc les of kne e did not dif fer sta tisti cally af ter flur bip ro fen or pla ce bo ad mi nis tra ti ons. Conc lu si on: Pa in sig ni fi cantly re du ced af ter sing le do se of trans der mal flur bip ro fen patch. Ho we ver, no sig ni fi cant dif fe ren ce in iso ki ne tic assess ment pa ra me ters was ob ser ved in the pre sent study. To as sess the ef fects of trans der mal flur bip ro fen and its ef fi cacy on kne e pa in and func ti on, furt her con trol led stu di es in lar ger gro ups of pa ti ents with dif fe rent do ses of flur bip ro fen are re com men ded.

Efficacy of a Single Dose Transdermal Flurbiprofen Administration in Patients with Knee Osteoarthritis