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ABS TRACT Ob jec ti ve: An gi o ten sin-con ver ting enz yme (ACE) is one of the key enz ymes in the re nin-an gi o ten sin-al dos te ro ne system which mo du la tes vas cu lar ten si on and blo od pres su re. Many aut hors ha ve re por ted an as so ci a ti on bet we en ACE-D al le le and co ro nary he art di se a se and ot her car di o vas cu lar di se a ses. The mec ha nism un derl ying the po si ti ve as so ci a ti ons bet we en the ACE-D al le les and di se a ses are not yet cle ar. Al te ra ti ons of the re nin-an gi o ten sin system ha ve be en imp li ca ted in the pat ho ge ne sis of va ri o us di se a ses. Se ve ral an gi o ten sin I con ver ting enz yme in hi bi tors and an an gi o ten sin II re cep tor bloc ker we re de mons tra ted to ha ve a cli ni cally im por tant proph ylac tic ef fect in mig ra i ne. Pre vi o us re ports sho wed an asso ci a ti on bet we en mig ra i ne wit ho ut au ra and ACE-D al le le poly morp hism. In this study it is ai med to eva lu a te whether the DD ge noty pe co uld al so be as so ci a ted with the fre qu ency and du ra ti on of mig ra i ne wit ho ut au ra (Mo A) and mig ra i ne with au ra (MwA). Ma te ri al and Met hods: One hundred one mig ra i ne pati ents (37 Mo A, 64 MwA) and 101 he althy non-mig ra i no us con trols from the re gi on of Eas tern Tur key we re inc lu ded in this study. The ge noty pe cha rac te ris tics we re de ter mi ned by the PCR analy sis using DNA ex trac ted from pe rip he ral blo od. Re sults: The re was no sig ni fi cant dif fe ren ce in al le lic fre qu ency (I and D) and ge noty pe poly morp hism (DD, DI and II) of the ACE ge ne in mig ra i ne pa ti ents and con trols (ge noty pe fre qu ency: p= 0.08). ACE ge noty pe dis tri bu ti on was si mi lar in mig ra i ne pa ti ents and he althy con trol gro ups. Tur kish pa ti ents Mo A and MwA did not sho w any dif fe ren ce in in ci den ce of the ACE-DD ge noty pe. Conc lu si on: We conc lu de that the I/D poly morp hism at the ACE lo cus do es not play any ro le in the pat ho ge ne sis and prog res si on of mig ra i ne.

türkiye klinikleri tıp bilimleri dergisi

Is There a Relation Between Insertion/Deletion Polymorphism of the Angiotensin Converting Enzyme Gene in Patients of Migraine with Aura and Migraine without Aura in Region of Eastern Turkey?