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ABS TRACT Ob jec ti ve: The aim of this study is to re vi ew our ex pe ri en ce with Pe gap ta nib in pa ti ents with ne o vas cu lar age-re la ted ma cu lar de ge ne ra ti on (AMD) and to de ter mi ne whet her out co mes wo uld be im pro ved by com bi ning Pe gap ta nib with pho tody na mic the rapy (PDT). Ma te ri al and Met hods: Ins ti tu ti o nal, ret ros pec ti ve ca se se ri es. The charts of 20 pa ti ents with ne o vas cu lar AMD who re ce i ved Pe gap ta nib mo not he rapy or com bi ned ocu lar PDT with Ver te por fin we re retros pec ti vely re vi e wed. Ma in out co me me a su res con sis ted of the num ber of tre at ments app li ed, Snel len best-cor rec ted vi su al acu ity (BCVA), an gi og rap hic le si on cha rac te ris tics and cen ter fi eld thick ness (CFT) in op ti cal co he ren ce to mog raphy (OCT). Re sults: Ave ra ge fol low-up ti me was 7.7 months (ran ge, 3-12 months). Ten pa ti ents (50%) we re in Pe gap ta nib mo not he rapy gro up (Gro up A) and 10 pa ti ents we re in com bi na ti on the rapy with PDT gro up (Gro up B). Pa ti ents in both gro ups re ce i ved 2 to 9 (me an, 5.2) Pe gap ta nib in jec ti ons. Gro up B re ce i ved 1 to 4 (me an, 1.8) PDT tre at ments. Ini ti al BCVA ran ged from 20/50 to 20/3200 (me an, 20/509), fi nal BCVA ran ged from 20/70 to 20/3200 (me an, 20/759). In gro up A, the me an ini ti al and fi nal BCVA we re 20/650 and 20/617, res pec ti vely (p= 0.590). The cor res pon ding num bers in gro up B we re 20/398 and 20/1060, res pecti vely (p= 0.062). Fo ur of the 10 eyes (40%) in Gro up B lost three li nes or mo re. No ne of the eyes in Gro up A lost three li nes or mo re vi si on (p= 0.087). The re was ne it her sig ni fi cant chan ge in the le si on si ze (p= 0.513), nor in CFT (315 μm to 268 μm, p= 0.99). Conc lu si on: The re sults of this study sug gest that com bi ned ocu lar PDT and Pe gap ta nib tre at ment may not be su pe ri or to Pe gap ta nib alo ne in pa ti ents with ne o vas cu lar AMD. Furt her stu di es are ne e ded.

Pegaptanib Versus Combined Pegaptanib and Photodynamic Therapy for Neovascular Age-Related Macular Degeneration