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ABS TRACT Ob jec ti ve: Sil de na fil, which is used for the tre at ment of erec ti le dysfunc ti on, has be en shown to in hi bit inf lam ma ti on in an ani mal mo del of ast hma. We ai med to de ter mi ne the im pact of ne bu li zed sil de na fil on lung his to logy in a mu ri ne mo del of chro nic ast hma. Material and Met hods: Forty-two BALB/c mi ce we re di vi ded in to six gro ups; A, B, C, D, E, and the con trol gro up. All gro ups ex cept con trols we re sen si ti zed and chal len ged with oval bu min. Then, mi ce in Gro up A re ce i ved ne bu li zed sa li ne. Ne bu li zed sil de na fil cit ra te was administered to Gro up B, C, and D at con cen tra ti ons of 0.035 mg/ml, 0.07 mg/ml, and 0.105 mg/ml res pec ti vely, and ne bu li zed bu de so ni de was administered at a con cen tra ti on of 0.25 mg/ml to Gro up E for 15 mi nu tes on ce a day, for a we ek. Ani mals we re sac ri fi ced 24 ho urs af ter the last in ha la ti o nal ex po su re and the air way samp les we re eva lu a ted his to lo gi cally by light and elec tron mic ros co py. Re sults: All the his to lo gic para me ters of ast hma in Gro up B we re sig ni fi cantly ame li o ra ted when com pa red to the ones in Gro up A. In Gro ups C and D, all the pa ra me ters ex cept thick nes ses of su be pit he li al smo oth musc le la yers we re sig ni fi cantly im pro ved when com pa red to Gro up A. Thick nes ses of ba se ment mem bra ne, su be pit he li al smo oth musc le, and epit he li um we re sig ni fi cantly smaller in Gro up B than Gro up E. Thick nes ses of ba se ment mem bra ne and su be pit he li al smo oth musc le we re sig ni fi cantly smaller in Gro up C than Gro up E. Thick ness of su be pit he li al smo oth musc le was sig ni fi cantly smaller in Gro up D than Gro up E. Conc lu si on: The res pon ses re gar ding im pro ve ment in ast hma pat ho logy we re fo und bet ter with all do ses of ne bu li zed sil de na fil than pla ce bo and even ne bu li zed ste ro id.

Impact of Nebulized Sildenafil on Lung Histology in a Murine Model of Chronic Asthma