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ABS TRACT Ob jec ti ve: In this study, it was ai med to in ves ti ga te in vit ro ac ti vi ti es of li ne zo lid combi ned with van comy cin, te i cop la nin, fu si dic acid, and cip rof lo xa cin aga inst Gram-po si ti ve pat ho gens. Ma te ri al and Met hods: This study was con duc ted at Ege Uni ver sity, Fa culty of Phar macy, De part ment of Phar ma ce u ti cal Mic ro bi o logy. Cli ni cal iso la tes used in this study we re ob ta i ned retros pec ti vely from the col lec ti on of Ege Uni ver sity Me di cal Fa culty, De part ment of Mic ro bi o logy and Cli ni cal Mic ro bi o logy, Bac te ri o logy La bo ra tory. Mi ni mal in hi bi tor con cen tra ti ons (MICs) of test stra ins_met hi cil lin-sus cep tib le Staph ylo coc cus au re us (MSSA), met hi cil lin-re sis tant S. au re us (MRSA), van comy cin in ter me di a te S. au re us (VI SA), Mu50 (van comy cin in ter me di a te S. au re us stra in), met hi cil lin-sus cep tib le Staph ylo coc cus epi der mi dis (MSSE), met hi cil lin-re sis tant S. epider mi dis (MRSE), van comy cin-sus cep tib le En te ro coc cus fa e ca lis (VSE) and van comy cin-re sis tant E. fa e ca lis (VRE)) we re de ter mi ned by mic ro di lu ti on met hod. Ti me-kill stu di es we re per for med over 24 h using an ino cu lum of 5 x 106 and 1 x 107 CFU/mL. An ti bi o tics we re tes ted at con cen tra ti ons 1x and 4 x MIC (minimum inhibitory concentration). Re sults: Synergy was de tec ted bet we en li ne zo lid plus te i cop la nin and fu si dic acid at 1 x MIC con cen tra ti ons in MSSA stra in. In MRSE stra in, li ne zo lid sho wed the sa me ef fect with fu si dic acid at 1xMIC. An ta go nis tic ef fect was fo und li ne zo lid plus van comy cin and te i cop la nin (4 x MIC) in VSE and li ne zo lid plus cip rof lo xa cin (4 x MIC) in MRSE stra in. Conc lu si on: In this study, li ne zo lid plus fu si dic acid ap pe a red to be the most ac ti ve com bi na ti on aga inst Gram-po si ti ve pat ho gens.

İn Vitro Activity of Linezolid in Combination with Vancomycin, Teicoplanin, Fusidic Acid, and Ciprofloxacin Against Gram-Positive Pathogens