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ABS TRACT Objective: Our aim was to in ves ti ga te the chan ges in Tc-99m tet ro fos min up ta ke and wash-out in the thyro id gland of nor mal vo lun te ers and Has hi mo to’s thyro i di tis (HT) pa ti ents with eit her euth yro i dism or hypoth yro i dism. Ma te ri al and Met hods: Thirty-fo ur pa ti ents with HT (10 hypoth yro id and 24 euth yro id) and 10 euth yro id he althy vo lun te ers we re en rol led in the study. In all ca ses, thyroid stimulating hormone (TSH), fre e thyro xi ne (FT4), fre e tri i o doth yro ni ne (FT3), an ti-thyro id an ti bo di es and thyro id vo lu me we re me a su red. An te ri or thyro id ima ges we re ac qu i red at 10, 30 and 120 min af ter in tra ve no us in jec ti on of 740 MBq Tc-99m tet ro fos min. Thyro id/ back gro und (T/B) ra ti os at 10, 30 and 120 min and wash-out in di ces (WI %) at 30 and 120 min we re cal cu la ted. Re sults: In all gro ups, ini ti al and la te tet ro fos min T/B va lu es did not dif fer from he althy con trol ca ses. At 120 min, the me an WI% of pa ti ents with hypoth yro i dism was sig ni fi cantly hig her than that of vo lun te ers; ho we ver this gro up is not sta tis ti cally dif fe rent from the euth yro id gro up. The va lu e WI % at 120 min was sig ni fi cantly cor re la ted with an ti-Tg an ti body le vels (r= -0.673; p= 0.033). In the euth yro id gro up, both an ti-TPO an ti body le vels and thyro id vo lu me had sig ni fi cant cor re la ti ons with the T/B ra ti os at 10, 30 and 120 min (r= 0.499, p= 0.013; r= 0.424, p= 0.039; r=0.528, p= 0.008 for An ti-TPO An ti body, and r= 0.577, p= 0.003; r= 0.606, p= 0.002; r= 0.645, p= 0.010, for thyro id vo lu me, res pec ti vely). Conc lu si on: We can conc lu de that Tc-99m tet ro fos min up ta ke and wash-out ki ne tics in thyro id tis su e may be chan ged with au to im mu ne thyrocy te des truc ti on in HT.

Changes of Thyroidal Tc-99m Tetrofosmin Uptake and Wash-Out in Patients with Hashimoto’s Thyroiditis