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86 rogesterone is the primary hormone secreted during the luteal phase of the menstrual cycle, which makes endometrium receptive to implantation of an embryo. The elevation of serum progesterone due to premature luteinization (PL) before ovulation trigger is generally prevented by suppressing luteinizing hormone secretion with a gonadotropin-releasing hormone agonist or antagonist during controlled ovarian hyperstimulation. However, despite these treatments, high serum progesterone levels can still be observed on the day of ovulation trigger probably due to high dose gonadotropins and may shift the endometrial window of receptivity.1 Elevated late follicular phase progesterone levels are usually defined as the serum progesterone levels of ≥1.5 ng/L on the day of ovulation trigger. In previous studies, it was reported that the incidence of premature luteinization varies from 10% to 40% during the stimulated in vitro fertilization cycles (IVF).2

Do High Dose Progesterone Levels Affect Clinical Pregnancy Rates in Freeze-All Cycles?