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Objective: The role of oxidative metabolism on in vitro fertilization (IVF) has not been studied in detail. Our aim was to investigate the impact of oxidative stress markers on subsequent oocyte and embryo quality. Material and Methods: A total of 214 oocytes and their corresponding follicular fluid (FF) samples from 67 women undergoing intracytoplasmic sperm injection (ICSI) were assessed. The relationship between FF levels of oxidative stress markers [malondialdehyde (MDA), nitric oxide (NO) and protein carbonyl] levels and subsequent oocyte quality, fertilization and embryo morphologies were evaluated. Results: The mean MDA levels were significantly higher in FFs of fertilized oocytes. The mean NO levels were significantly lower in FFs of top-quality embryos whereas mean protein carbonyl levels were significantly higher in FFs of top quality embryos. Conclusion: FF oxidative stress seems to play an important role in fertilization and embryo morphology. Different oxidative stres pathways might have different effects on oocyte development, and also particular oxidative stress in FF might be needed for oocyte maturation.

Effect of Follicular Fluid Oxidative Stress on Subsequent Oocyte Quality and Embryo Development