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biomarker is a biologic feature that can be used to detect the presence or the progress of a disease. It is important to define the threshold limit value (TLV) of a biomarker in diagnostic medicine. The TLV is a level of the biomarker to which it is believed that a patient can be free from a disease. The TLV of a biomarker should be accurate to define the presence or absence of a disease status. The diagnostic accuracy A Detecting Diagnostic Accuracy of Biomarkers Through a Bivariate Beta Distribution