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Pulmonary alveolar microlithiasis (PAM) is a rare, diffuse lung disease characterized by intra-alveolar microliths. The disease is often diagnosed incidentally and it is usually seen as a primary disease. Turkey is one of the most prevalent countries of this entity. However, pulmonary alveolar proteinosis (PAP) which is characterized by deposition of intra-alveolar Periodic AcidSchiff positive protein and lipid rich material may occurs primarily or secondarily to any malignancies (especially Hematologic Malignancies). Therefore, the lung lesions, especially in computerized tomography, with widespread significant ground-glass appearance of a patients with hematologic malignancy are mostly thought as PAP. In this article, we reported a case with PAM who had advanced Diffuse Large B cell lymphoma, no pulmonary symptoms and the changes observed in lung tomography were firstly interpreted in favor of PAP due to atypical radiologic feature for PAM. Additionally, we emphasized importance of lung biopsy in cases with PAM that they have with atypical radiologic feature.

türkiye klinikleri akciğer arşivi/türkiye klinikleri akciğer arşivi :

Pulmonary Alveolar Microlithiasis with Atypical Radiologic Feature: A Rare Differential Diagnosis of Pulmonary Alveolar Proteinosis in a Patient with Hematologic Malignancy: Case Report