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Aim: We conducted this study to determine the increase rate of mortality and effect of anesthesia in covid-19 patients with severe vitamin D deficiency. Study Design: Observational study Place and Duration: King Salman Armed Forces Hospital Tabuk, Saudia Arabia/ Rashid Latif Medical College, Lahore. Jan 2021-Jun 2021 Materials &amp; Methods: One hundred and seven patients, both males and females, with pandemic disease (coronavirus) were included in the study. Patients ranged in age from 16 to 80 years. Following the receipt of written consent, demographic information such as age, gender, and BMI were collected and analysed. A 5 mL blood sample was taken from each patient in order to determine their vitamin D levels. Patients in the intensive care unit (ICU) who were seriously ill or experiencing severe pain were given general anaesthesia. If 25(OH)D was less than 25 nmol/L (10 ng/dL), severe vitamin D deficiency was considered. The relationship between vitamin D deficiency and the rate of mortality among patients was investigated. The SPSS 25.0 version was used to analyze all of the data in this study. Results: 33.07±12.87 years were the mean age of the patients with mean BMI 23.01±6.32 kg/m2. Among 107 cases, most of the patients were males 67 (62.6%). Vitamin D deficiency was found among 55 (51.4%) patients in which most of the patients were serious ill those received anesthesia. We found that 33 (30.8%) patients were died in which most of the patients. Patients with covid-19 disease who had low vitamin D levels had a higher mortality rate than those who had normal vitamin D levels, according to a study that was statistically significant at the 0.04 level of significance. Conclusion: We concluded in this study that the patients with severe coronavirus disease with vitamin D deficiency had higher rate of mortality. Keywords: Severe Vitamin D Deficiency, Mortality, Anesthesia, Pandemic Disease

Deficiency of Vitamin D Lead to Death in Patients with Covid 19