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Background: The Helicobacter pylori is a gram negative bacterium which is found in majority of population in all over the world. It is possible due to contaminated food consumption, working in unsanitary condition and the use of public toilets with poor sanitation. In the field of gastroenterology infection caused by H. pylori and functional dyspepsia are most common clinical issue but their association is also unclear. Aim: To determine the frequency of Helicobacter Pylori in patients with presenting with Dyspepsia in Civil Hospital, Khairpur Study Design: Descriptive Cross sectional study. Duration of study: One year from 01-Jan- 2019 to 31-12-2019.  Setting: Institute of Microbiology, Shah Abdul Latif University, Khairpur.  Methodology: All the patients between 15 to 60 years of age, admitted patients of dyspepsia were diagnosed and evaluated for Helicobacter pylori infection through histopathological examination.  Results: Total 100 subjects with dyspepsia were screened for Helicobacter pylori infection. Mean age of patients was 40.0 ±15.40. Majority of patients with H. pylori positive were from age group between 40-60 years, from which 56.7% of them were H. pylori positive; while 30% of patients were from age between 20-40 years of age and only 13.3% were from age below 20 years of age  Conclusion: The dyspeptic patients are prone to acquire Helicobacter pylori infection therefore present study reported 30% prevalence for H. pylori infection with male gender predominance. Key words: Dyspepsia, Helicobacter Pylori Infection, Peptic ulcer, histopathology, endoscopy

Frequency of Helicobacter Pylori in Patients with Dyspepsia in Civil Hospital, Khairpur