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SAMMENDRAG Fa epidemiologiske undersokelser har undersokt betydningen av de klassiske risikofaktorer for hjerteinfarkt i begge kjonn innenfor samme studiepopulasjon. Det har ikke vaert avklart om royking er en like viktig risikofaktor for kvinner og menn. Sammenhengen mellom royking, serumlipider, blodtrykk og hjerteinfarkt ble undersokt blant 11 843 menn og kvinner i alderen 35-52 ar som deltok i Finnmarkundersokelsen i 1977-78 og som deretter ble fulgt i 12 ar. I alt registrerte vi 495 tilfeller av forstegangs hjerteinfarkt blant menn og 103 tilfeller blant kvinner. Insidensraten var 4,6 ganger hoyere blant menn. Insidensen var seks ganger hoyere blant kvinner og tre ganger hoyere blant menn som roykte minst 20 sigaretter daglig sammenlignet med aldri-roykere av samme kjonn. Daglig royking var en sterkere risikofaktor for infarkt hos kvinner (RR 3,3; 95% KI, 2,1–5,1) enn hos menn (RR 1,9; 95% KI, 1,6–2,3) etter justering for andre risikofaktorer. Blant personer yngre enn 45 ar pa undersokelsestidspunktet var kjonnsforskjellen assosiert med royking storre (kvinner: RR 7,1; 95% KI, 2,6–19,1) (menn: RR 2,3; 95% KI, 1,6–3,2). Serum totalkolesterol, HDL kolesterol, systolisk blodtrykk og blodtrykkbehandling var ogsa signifikante prediktorer, med relativ risiko-estimater av samme storrelsesorden i de to kjonn. Njolstad I, Arnesen E, Lund-Larsen PG. Smoking – an important risk factor for myocardial infarction among middle-aged women and men. A 12-year follow-up of the Finnmark study. Nor J Epidemiol ENGLISH SUMMARY Few epidemiological studies have investigated the relative importance of major coronary risk factors in the two sexes within the same study population. In particular, it is not clear whether smoking carries a similar risk for coronary heart disease in men and women. The associations between smoking, serum lipids, blood pressure and myocardial infarction were examined in a population-based prospective study of 11 843 men and women aged 35 to 52 years at entry. During 12 years, 495 cases of first myocardial infarction among men and 103 cases among women were identified. Myocardial infarction incidence was 4.6 times higher among men. The incidence was increased sixfold in women and threefold in men who smoked at least 20 cigarettes per day compared with never-smokers, and the rate in female heavy smokers exceeded that of never-smoking men. Multivariate analysis identified current smoking as a stronger risk factor in women (relative risk, 3.3; 95% confidence interval [CI], 2.1–5.1) than in men (relative risk, 1.9; 95% CI, 1.6–2.3). Among those under 45 years old at entry, the smoking related sex difference was more pronounced (in women: relative risk, 7.1; 95% CI, 2.6–19.1) (in men: relative risk, 2.3; 95% CI, 1.6–3.2). Serum total cholesterol, HDL cholesterol and systolic blood pressure were also highly significant predictors in both sexes. 1997; 7 (2): 183-189.

Røyking – en viktig risikofaktor for hjerteinfarkt blant middelaldrende kvinner og menn. En 12-års oppfølging av Finnmarkundersøkelsen