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SAMMENDRAG Ved Institutt for samfunnsmedisin, Universitetet i Tromso, er det over mange ar bygget opp en landsdekkende prospektiv undersokelse kalt ’Kvinner, livsstil og helse’/’Kvinner og kreft’. Studien er primaert designet for a undersoke risikofaktorer for kreft, og i saerdeleshet brystkreft. Siden 1991 har droyt 100 000 tilfeldig utvalgte kvinner, fodt 1927-1965, blitt inkludert i studien. Svarprosenten er omlag 60. Deltakerne har fylt ut et sporreskjema med noe varierende innhold, men med en del felles kjernesporsmal. Detaljgraden nar det gjelder kostholdsinformasjon varierer. Av de vel 100 000 kvinnene som deltar har omlag halvparten fylt ut et oppfolgingsskjema. Vi er saerlig interessert i a studere en eventuell effekt av et hoyt fiskekonsum pa kreftrisiko. Sporsmalene om konsum av fisk og fiskeprodukter er validert mot fettsyresammensetningen i serum fosfolipider. Studien inngar i multi-senter prosjektet EPIC – the European Prospective Investigation into Cancer and Nutrition. For a kunne sammenlikne kostdata fra de ti deltakerlandene er det utarbeidet en intern kalibreringsmetode basert pa et strengt standardisert dataprogram for 24-timers kostholdsintervju. I Norge vil det bli gjennomfort omlag 1800 kostholdsintervju over telefon. Hjartaker A, Engeset D, Brustad M, Lund E. Fish consumption and cancer risk among Norwegian women – The Norwegian Women and Cancer Study (NOWAC). Nor J Epidemiol 2000; 10 (1): 63-70. ENGLISH SUMMARY The Norwegian Women and Cancer study, NOWAC (in Norwegian: ’Kvinner, livsstil og helse’/’Kvinner og kreft’) is a large population-based cohort study primarily designed to examine factors related to cancer, other illnesses, and mortality in a prospective manner. In particular, it is designed for investigation of breast cancer. Since the establishment in 1991, more than 100 000 Norwegian women born 1927-1965 have been included in the cohort. The participants are randomly sampled, and the response rate is about 60%. The participants have received a mailed letter of invitation requesting informed consent and a self-instructive questionnaire. After sufficient follow-up time, events will be identified by linkage to the Cancer Registry of Norway and to the registry of death certificates at Statistics Norway. Dietary data have been collected through a food frequency approach. Some 70 000 women have given detailed information about their diet during the last year, whereas more scarce dietary data are collected from the rest of the participants. A large number of the women have reported their dietary intake twice. Along with information on “usual” diet, special attention is given to the consumption of marine foods. Based on earlier findings we want to examine a potential protective effect of fish consumption on breast cancer risk. The questions on marine food consumption have been validated against serum phospholipid fatty acid composition. In addition to the national analyses, NOWAC is part of the large multi-centre study EPIC – the European Prospective Investigation into Cancer and Nutrition. To calibrate dietary data across centres a computer based 24-h recall program is developed. A sub-sample of about 1800 of the NOWAC participants will be interviewed using this program. The interviews are performed by telephone. Building a biological bank is another important part of EPIC, and we are planning to collect blood samples via mail for a sub-sample of the Norwegian participants.

Fiskekonsum og kreftrisiko blant norske kvinner - The Norwegian Women and Cancer Study (NOWAC)