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Rhesus (Rh) antigen was discovered in 1940 by Karl Landsteiner andWiener. In later years, because of its immunogenecity along with ABO grouping, RhDantigen testing was made mandatory before issuing a compatible blood. Presently thereare five major antigens i.e. D, C, E, c and e in Rh blood group system.Aims: To know the distribution of major Rh antigens, its phenotype and most probablegenotype in the population of Gwalior region i.e. Central India.Place and Duration of Study: This study was carried out at Blood Bank, Department ofPathology, Gajra Raja Medical College, Gwalior, India from 1st October 2008 to 30thSeptember 2010.Methodology: The distribution of Rh antigens, its phenotype and most probable genotypewas studied in 1000 samples collected from blood donors, blood recipients and otherpatients. Samples were tested for ABO blood group and five major antigens of Rh systemby tube agglutination method /or by gel technology.Results: Out of 1000 samples studied, the incidence of RhD was 91.6% and only 8.4%samples were negative for D antigen (p=.5). The Incidence of other Rh antigens i.e. C, E, c and e was 84%, 25.6%, 58.3% & 78.5% respectively (p=.5) Most commonphenotype in RhD positive samples were DCCee (41%) and in RhD negative it was dccee(5.6%) (p= .5). Eleven samples (1.1%) were negative for antithetical antigens E &e. Most probable genotype in order of frequency was DCe/DCe (R1R1)-41%, DCe/Dce(R1R0)-25.5% & dce/dce (rr)-5.6% (p= .5).Conclusion: Like previous studies, our study also concluded that there is a wide range ofracial and geographical variation in the distribution of Rh phenotype and genotype. TheRh blood group system has vital role in population genetic study, in resolving medico legalissues and more importantly in transfusion practice

Incidence of Rh Antigens, Phenotype & Probable Genotype in the Population of Gwalior and Chambal Region, Central India